Bioinformaticist Project Scientist

📁
Research/Science
💼
MB-Molecular Biophys & Integ Bio
📅
89573 Requisition #

Berkeley Lab’s Molecular Biophysics & Integrated Bioimaging Division has an opening for a Bioinformaticist Project Scientist. You will work on a project that will integrate macromolecular X-ray crystallography (MX) and Small Angle X-ray scattering (SAXS) at the molecular level for structural characterization, with computational structure prediction methods to study structure, dynamics of non-coding RNA’s and its de novo design. The project will be carried out at the SIBYLS beamline and National Center for X-ray Tomography (NCXT) at the Advanced Light Source (ALS). You will be responsible for troubleshooting RNA purification for structural studies as well as the cell specimen preparation for SXT and evolve their structural and imaging characterization skills with staff at the ALS synchrotron. You will leverage their expertise in integrating structural and cell biology of non-coding RNAs within the scope of DNA repair to discover mechanisms by which noncoding RNAs impact the DNA-repair in the cancer cell.

 

What You Will Do:

  • Preparation of cell specimen for Soft X-ray tomography (SXT).

  • Data acquisition at the SXT microscope at the National Center for X-ray Tomography (NCXT).

  • Perform analysis of SXT images and SXT reconstructions to investigate the topology of the chromatin and nucleoid.

  • Participate with other members of the SIBYLS team in the design and implementation of instrumentation and methodology that will maximize efficient and productive data analysis from macromolecular X-ray crystallography (MX) and Small Angle X-ray scattering (SAXS).

  • Effectively communicate with the other members in the group and provide implementation plans that include a timeline, procedures, expected outcomes, and risks.

  • Participate in cross-team and cross-group collaborative projects.

  • Present research at international conferences and publish in high-impact, peer-reviewed journals.

  • Create periodic reports to the management and principal investigators of the program.

  • Work independently, maintain appropriate records and manage data to ensure accessibility and replication of work.

  • Lead group meetings.


Additional Responsibilities as needed:

  • May supervise undergrads or research assistants.

 

What Is Required:

  • At least 4 years of experience in integrating macromolecular X-ray crystallography (MX) and Small Angle X-ray scattering (SAXS). 

  • At least 3 years of experience in acquiring and analyzing Soft X-ray tomography data. 

  • Experience in developing novel approaches in the segmentation of SXT reconstruction using AMIRA or CHIMERA.

  • Experience in the purification of proteins.

  • Experience in the purification of non-coding RNA’s.

  • Experience in culturing and characterization of cell cultures.

  • Specific experience in macromolecular crystallography.

  • Experience with SAXS base solution structure modeling. 

  • Demonstrated experience in managing multiple projects in parallel and in corresponding with scientific collaborators. 

  • Demonstrated success in the publication of high-impact work in internationally recognized peer-reviewed journals.

  • Effective interpersonal skills and demonstrated ability to work in a team environment with a diverse group of scientific and technical personnel. 

  • Strong written and verbal communication skills.

 

Additional Desired Qualifications:

  • Ph.D. degree in Biochemistry, Structural Biology or related field or equivalent experience.

  • Designing high-throughput and automated systems for acquiring SXT and SAXS data.   

  • Familiarity with various structural biology -related software and tools (Phenix, SCATTER, FoXS, BILBOMD etc.).

  • Python programming.

 

The posting shall remain open until the position is filled.

 

Notes: 

  • This is a full time, 1 year, term appointment with the possibility of extension or conversion to Career appointment based upon satisfactory job performance, continuing availability of funds and ongoing operational needs.

  • Full-time, M-F, exempt (monthly paid) from overtime pay.

  • Salary is commensurate with experience.

  • This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.

  • Work will be primarily performed at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.


Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science.

 

Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4.  Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."

 


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Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."

 

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The Lawrence Berkeley National Laboratory provides accommodation to otherwise qualified internal and external applicants who are disabled or become disabled and need assistance with the application process. Internal and external applicants that need such assistance may contact the Lawrence Berkeley National Laboratory to request accommodation by telephone at 510-486-7635, by email to eeoaa@lbl.gov or by U.S. mail at EEO/AA Office, One Cyclotron Road, MS90R-2121, Berkeley, CA 94720. These methods of contact have been put in place ONLY to be used by those internal and external applicants requesting accommodation.