Computational Biologist Research Scientist

📁
Research/Science
💼
BE-Biological Systems & Eng
📅
91996 Requisition #

Lawrence Berkeley National Lab’s (LBNL) Biological Systems & Engineering Division has an opening for a Biologist Research Scientist to join the team.

 

In this exciting role, you will develop multiple biotechnology relevant hosts including Pseudomonas putida to produce biofuels and bioproducts. You are part of the Host Engineering group led by Dr. Aindrila Mukhopadhyay, and part of the Biofuel and Bioproducts Division at the Joint BioEnergy Institute (JBEI) in Emeryville, CA. Specifically, the project has two main goals. 1. Generating strains that have been engineered to scale in a reliable or predictable manner. For this, background, engineered, and modified strains will be examined under a variety of cultivation modes and scales using multi-omics methods. The resulting systems biology data will be used to develop Biodesign approaches to build host chassis that can maintain production phenotype in a stable and reliable manner for longer periods of time in cultivation regimes required for industrial scale-up and production 2. Generating strains that show high productivity in industrial conditions – such as low oxygen, high gravity, and mixed carbon source regimes.

 

What You Will Do:

  • Evaluate microbial strain physiology during scale-up and other industrially relevant conditions. 
  • Identify genetic modifications required to improve strain performance and stability during scale-up and using industrially relevant carbon sources (mixed carbon, hydrolysate).
  • Implement hypotheses from metabolic models to generate complex engineered strains. 
  • Examine wildtype, engineered, and libraries of genetically altered microbial strains in a range of cultivation modes and regimes – to collect growth and production data, and samples for multi-omics experiments (RNAseq, resequencing, protein, metabolite, and fluxomic analysis).
  • Integrate multi-omics data into mechanistic models of key cellular responses relevant to production phenotypes.
  • Collaborate with analytical and computational teams at JBEI and Lab user facilities, to develop context specific metabolic and stress response models that impact production levels and production phenotype stability. Determine the parameters that are required to be measured to refine models and improve model predictability. 
  • Develop tools to deploy genetic modifications and biodesign strategies in key microbial hosts. 
  • Demonstrate an increase in strain capacity to maintain high productivity for longer periods of time – specifically in strains such as P. putida.
  • Lead the development and authorship of peer-reviewed publications. 
  • Maintain an accurate and detailed scientific logbook of all experiments performed.  Ensure that others could duplicate results.

 
Additional Responsibilities as needed:

  • Train research assistants and assist others in the lab who require guidance with computational methods and data analysis.
  • Serve as work lead for research assistants and research associates in the project. 
  • Assist with writing research proposals, peer-reviewed publications and records of inventions. 
  • Take responsibility of a key piece of equipment or lab area. 
  • Maintain an electronic lab notebook, maintain appropriate records and manage data, archive strains and plasmids. 
  • Provide detailed six monthly reports that can be used as part of the manuscript for peer-reviewed journals. 

 
What is Required:

  • 3 to 4 years of relevant experience in biotechnology applications that use microbiology, molecular biology, systems biology, metabolic modeling research and development in microbial systems beyond the highest degree in Biological Sciences, Molecular Biology, or Microbiology.
  • Experience with computational strain design methods using genome scale metabolic models.
  • Experience with hypothesis generation using context specific genome scale models and provide. experimentally implementable strategies for engineering an improved production strain.  
  • Experience in MATLAB or python, specifically as they pertain to functional genomics analyses and metabolic modeling
  • Experience with developing genetics tools. 
  • Experience with growth and culturing non – model microbes.
  • Experience applying high-throughput approaches to strain engineering.
  • Strong publication record. 
  • Experience with undertaking a mechanistic evaluation of regulation and transcription in biological systems.
  • Experience with working in collaboration with user-facilities and other computational/analytical teams.  
  • Experience with scientific journal writing submissions and ability to write reviews.
  • Demonstrated ability to work well independently as well as a part of a diverse team.
  • Effective interpersonal, verbal and written communication skills, including public-speaking and presentation skills.
  • Ability to troubleshoot problems, recommend actions and serve as work lead for research assistants and research associates.
  • Advanced analytical, organizational, and record-keeping skills.

 
Desired Qualifications:

  • Ph.D. degree in Biological Sciences, Molecular Biology, or Microbiology.

Notes:

  • This is a full time, 1 year, career-track term appointment that may be renewed to a maximum of five years and that may be converted to career based upon satisfactory job performance, continuing availability of funds, and ongoing operational needs.
  • This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
  • Diversity, equity, and inclusion are core values at Berkeley Lab. Our excellence can only be fully realized by faculty, students, and staff who share our commitment to these values. Successful candidates for our faculty positions will demonstrate evidence of a commitment to advancing equity and inclusion.
  • Work will be primarily performed at JBEI — Bldg. 978, 5885 Hollis St., 4th floor, Emeryville, CA

 

Biological Systems and Engineering Division

Vision: To lead efforts that combine the power of biology with the tools of engineering to develop sustainable energy and biomanufacturing solutions and improve human health.

Mission: Advance a mechanistic and predictive understanding of complex biological systems over multiple scales in terms of their responses to manipulation, stress, disease and environmental challenges and translate this knowledge using engineering principles to develop resilient systems, tools, and processes for the efficient production of fuels, chemicals, materials, tissues, and therapeutics.

 

Berkeley Lab

Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science.

 

Working at Berkeley Lab has many rewards including a competitive compensation program, excellent health and welfare programs, a retirement program that is second to none, and outstanding development opportunities.  To view information about the many rewards that are offered at Berkeley Lab- Click Here.

 

Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4.  Click here to view the poster and supplement: "Equal Employment Opportunity is the Law.

 

Lawrence Berkeley National Laboratory encourages applications from women, minorities, veterans, and other underrepresented groups presently considering scientific research careers.

 

 

 

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Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."

 

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