Postdoctoral Fellow – Secondary Metabolites Discovery

📁
Postdoctoral Fellow
💼
JG-Joint Genome Institute
📅
89964 Requisition #

Berkeley Lab’s Joint Genome Institute (JGI) Division has an exciting new opportunity for a Molecular Biology Postdoctoral Scholar in the Secondary Metabolites Group.  JGI is committed to exploring the large chemical and biosynthetic space of secondary metabolites yet to be discovered. Microbes produce a wide variety of chemical compounds as secondary metabolites, which are not required for growth but often exhibit important biological activities, including modulating behaviors of surrounding organisms such as other microbes and plants. However, the majority of secondary metabolites a given microbe is capable of producing has not been discovered in most cases. 


The successful Postdoc will be responsible for developing new functional genomics technologies that will enable rapid and large-scale discovery of secondary metabolites from microbes. The Postdoctoral Fellow will use a panel of high throughput technologies including genome-wide engineering, NGS, metabolomics, flow cytometry, and DNA synthesis to achieve this goal.

 

What You Will Do:

  • Work independently and as a member of interdisciplinary research teams.

  • Develop genome-wide mutant library construction and high throughput cultivation procedures.

  • Develop high throughput screening technologies that enable identification of mutants or culture conditions in which biosynthetic gene clusters of secondary metabolites are expressed.

  • Use NGS-based functional genomics technologies to understand the regulation of secondary metabolism.

  • Work with computational scientists to develop data analysis workflows.

  • Activate silent biosynthetic gene clusters and identify secondary metabolites produced by mutants.

  • Analyze data and report findings in peer-reviewed scientific journals and at conferences.

  • Interact with internal and external collaborators.

  • Assist other group members in designing and executing experiments, interpreting data, and writing research articles and grant applications.


What Is Required:

  • Ph.D. degree in Molecular Biology, Microbiology, Biochemistry, or related field.

  • Demonstrated ability to work in a dynamic and diverse team environment.

  • Strong record-keeping, and written and oral communication skills.

  • Extensive experience in molecular genetics in microbes, especially Actinomycetes or Pseudomonads.

  • At least, one of the following experiences is required:

    • Extensive experience in genome-wide mutant library construction and HTS.

    • Demonstrated experience in activating biosynthetic gene clusters and the identification of their products.

    • Extensive experience in genome-wide regulatory network analysis using NGS.


Additional Desired Qualifications:

  • Familiarity with analyzing NGS and metabolomics data.

  • Experience in flow cytometry.

  • Experience in microbial metabolite identification.

  • Experience in working with large DNA molecules.

  • Experience in using automated liquid handling systems.

 

To be considered please provide the following materials in your application:

1) Curriculum Vitae​ or Resume (1-3 pages)

2) Cover letter (2-page maximum)

3) Please include up to three references


The posting shall remain open until the position is filled.

 

Notes: 

  • This is a full time, 2 year, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.

  • M-F, exempt (monthly paid) from overtime pay.

  • This position is represented by a union for collective bargaining purposes.

  • Salary will be predetermined based on postdoctoral step rates.

  • This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.

  • Work will be primarily performed at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.

 

Learn About Us:

JGI & Berkeley Lab: A View to Fuel Innovative Science in the Public Interest

They say it’s all about location and Berkeley Lab has it all: a view above the San Francisco Bay, cool breezes, and world-class multidisciplinary science within a diverse and respectful research ecosystem of 5,000 people. Nearly 90 years ago, Ernest Orlando Lawrence, the inventor of the cyclotron, brought physicists, biologists, engineers and mathematicians together in Berkeley above the University of California campus to tackle the most urgent scientific challenges. Today, after garnering 13 Nobel Prizes, Berkeley Lab has sustained and grown that tradition of open, interdisciplinary team science, exemplified by how the U.S. Department of Energy Joint Genome Institute (JGI) addresses the most pressing energy and environmental challenges using integrative genome science approaches. JGI takes up residence in the new, state-of-the-art Integrative Genomics Building (IGB) along with the U.S. Department of Energy Systems Biology Knowledgebase (KBase) to expand the frontiers of energy and environmental science in partnership with the worldwide community of researchers. Will you join us and be a critical part of our next ground-breaking discoveries?


Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science.


Working at Berkeley Lab has many rewards including a competitive compensation program, excellent health and welfare programs, a retirement program that is second to none, and outstanding development opportunities.  To view information about the many rewards that are offered at Berkeley Lab- Click Here.


Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4.  Click here to view the poster and supplement: "Equal Employment Opportunity is the Law.


Lawrence Berkeley National Laboratory encourages applications from women, minorities, veterans, and other underrepresented groups presently considering scientific research careers.




Previous Job Searches

My Profile

Create and manage profiles for future opportunities.

Go to Profile

My Submissions

Track your opportunities.

My Submissions

Similar Listings

JG-Joint Genome Institute

Bay Area, California, United States

📁 Postdoctoral Fellow

Requisition #: 89367

GO-Energy Geosciences

Bay Area, California, United States

📁 Postdoctoral Fellow

Requisition #: 88128

MB-Molecular Biophys & Integ Bio

Bay Area, California, United States

📁 Postdoctoral Fellow

Requisition #: 89209

Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."

 

Privacy & Security Notice | LBNL is an E-verify Employer | Contact Us


The Lawrence Berkeley National Laboratory provides accommodation to otherwise qualified internal and external applicants who are disabled or become disabled and need assistance with the application process. Internal and external applicants that need such assistance may contact the Lawrence Berkeley National Laboratory to request accommodation by telephone at 510-486-7635, by email to eeoaa@lbl.gov or by U.S. mail at EEO/AA Office, One Cyclotron Road, MS90R-2121, Berkeley, CA 94720. These methods of contact have been put in place ONLY to be used by those internal and external applicants requesting accommodation.