Synthetic Biology – Genetically Encoded Material Synthesis Postdoctoral Scholar

📁
Postdoctoral Fellow
💼
JG-Joint Genome Institute
📅
88001 Requisition #

Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science.


Berkeley Lab’s Joint Genome Institute (JGI) Division has an opening for a Synthetic Biology – Genetically Encoded Material Synthesis Postdoctoral Scholar.  The Post-Doctoral Fellow working in the Yoshikuni Group is responsible for developing a biological 3D fabrication platform for synthesis of complex and potentially valuable genetically encoded hybrid materials (GEMs). For the present study, we selected CaCO3 GEMs as models. These GEMs are produced by many organisms (they make up avian and reptile eggshells, outer shells of some marine organisms, diatom shells, and nacre of mollusks) and their compositions are well characterized. However, their synthesis processes remain poorly understood. Therefore, successful delivery of the 3D fabrication platform could also provide:

 

  • Strategies to identify, characterize, and catalog genes and pathways controlling transport, modification, and synthesis of these GEMs

  • Testbeds to study and improve our knowledge of assembly mechanisms of these GEM formation

 

Additionally, the resulting GEMs should provide new opportunities for downstream applications (e.g., long-term carbon sink/limestone-like construction materials, metamaterials, photonic crystals, aluminum replacements, and artificial pearls). Furthermore, the knowledge obtained through this project will be directly applicable to making other types of GEMs.


What You Will Do:

  • Design and build constructs comprising multi-gene pathways

  •  Introduce dynamic regulation of pathway expression

  • Metabolic engineering of CaCO3 GEMs production

  • Fermentation

  • Characterization of Ca concentration in media and CaCO3 GEMs


What is Required: 

  •  Ph.D. degree in Biochemistry, Chemical Engineering, Bioengineering

  • Ability to work in a dynamic and diverse team environment

  • Strong written and oral communication skills


Additional Desired Qualifications:

  • Experience in molecular biology techniques (molecular cloning, DNA/RNA extraction, PCR, gel electrophoresis)

  • Experience in biochemical characterization of enzymes (protein purification, specific activity, steady-stateinetics)

  • Sequence-based enzyme analysis (e.g., BLAST, pfam search, Multiple Sequence Alignment, tree construction, visualization)


The posting shall remain open until the position is filled.


Notes: 

  • This is a full-time-year postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing the availability of funds and ongoing operational needs. You must have less than 3 years of paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.

  • Full-time, M-F, exempt (monthly paid) from overtime pay.

  • This position is represented by a union for collective bargaining purposes.

  • Salary will be predetermined based on postdoctoral step rates.

  • This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.

  • Work will be primarily performed at DOE Joint Genome Institute (JGI) —   1 Cyclotron Road, Berkeley, CA.


JGI & Berkeley Lab: A View to Fuel Innovative Science in the Public Interest

They say it’s all about location and Berkeley Lab has it all: a view above the San Francisco Bay, cool breezes, and world-class science within a diverse, respectful research ecosystem of 5,000 people. Nearly 90 years ago, Ernest Orlando Lawrence, the inventor of the cyclotron, brought physicists, biologists, engineers and mathematicians together in Berkeley above the University of California campus to tackle the most urgent scientific challenges. Today, after garnering 13 Nobel Prizes, Berkeley Lab has sustained and grown that tradition of open, interdisciplinary team science, exemplified by how the U.S. Department of Energy Joint Institute (JGI)  addresses the most pressing energy and environmental challenges. This summer, JGI takes up residence in the new, state-of-the-art Integrative Genomics Building (IGB) along with the U.S. Department of Energy Systems Biology Knowledgebase (KBase) to expand the frontiers of energy and environmental science in partnership with the worldwide community of researchers. Will you join us and be a critical part of the next ground-breaking discoveries in the public interest?


JGI is comprised of highly-skilled and diverse talent founded on a culture of scientific excellence, trust, curiosity, passion, and collaboration.


Working at Berkeley Lab has many rewards including a competitive compensation program, excellent health and welfare programs, paternal leave, a retirement program that is second to none, and outstanding employee development opportunities.  To view information about the many rewards that are offered at Berkeley Lab- Click Here.


Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4.  Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."

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Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."

 

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The Lawrence Berkeley National Laboratory provides accommodation to otherwise qualified internal and external applicants who are disabled or become disabled and need assistance with the application process. Internal and external applicants that need such assistance may contact the Lawrence Berkeley National Laboratory to request accommodation by telephone at 510-486-7635, by email to eeoaa@lbl.gov or by U.S. mail at EEO/AA Office, One Cyclotron Road, MS90R-2121, Berkeley, CA 94720. These methods of contact have been put in place ONLY to be used by those internal and external applicants requesting accommodation.